November 8, 2022
Above: The logos for the Healthy Nevada Project, DRI, and Renown Health.
Childhood Traumas Strongly Impact Both Mental and Physical Health
Adult risk for obesity, chronic pain, migraines, and mental disorders increases in proportion to the number and types of traumas experienced in childhood
The social environments we grow up in are critical when determining our wellbeing and health later in life. Most Americans (67%) report experiencing at least one traumatic event in childhood, and a new study shows that these experiences have significant impacts on our health risks as adults. Physical illnesses such as obesity and chronic pain are affected, but mental disorders show the most significant association, including post-traumatic stress disorder (PTSD), bipolar disorder, substance abuse, and depression.
Scientists from DRI and the University of Nevada, Reno, led the study, published on Oct. 6 in the journal Frontiers in Psychiatry. More than 16,000 people from the Reno area volunteered for the research as part of the Healthy Nevada Project, one of the most visible genomic studies in the United States powered by Renown Health. Participants answered questions about their social environments before age 18, including experiences with emotional, physical, or sexual mistreatment, neglect, and substance abuse in the household. The researchers combined this information with anonymized medical records to build on existing research about how childhood traumas affect health outcomes.
“The study provides insight as to how social determinants of health may influence adult health disorders,” said Robert Read, M.S., a researcher at the Center for Genomic Medicine at DRI and one of the study’s lead authors.
Nearly two-thirds (66%) of participants recalled at least one type of trauma, and almost one-quarter (24%) reported experiencing more than four. Women and people of African American and Latinx descent reported a higher prevalence of traumatic experiences than men and those with European ancestry, but people in low-income households were the most impacted.
Thirteen mental illnesses showed the most statistically significant associations, including mood disorders, depression, PTSD, anxiety disorders, eating disorders, schizophrenia, and substance abuse. For every reported type of abuse experienced in childhood, a participant’s risk for PTSD increased 47%. Each cumulative trauma also increased one’s risk for making a suicide attempt by 33%.
The researchers note that although the study is rooted in Nevada — which has high rates of adults with mental illness and poor access to care — it provides a window into deeply rooted public health issues across the nation.
“Combatting the prevalence of childhood traumas is a complex problem,” said Karen Schlauch, Ph.D., a bioinformatics researcher at DRI and one of the study’s lead authors. “Personal experiences with neglect and abuse are more challenging to address, but many of the underlying issues can be tackled at the community level, like food insecurity and poverty.”
Beyond improving our understanding of how early social environments influence our health, Schlauch says that the next target for research is understanding how childhood traumas may be linked with specific traits like impulsivity — a prominent trait in Nevada’s gambling communities.
“In order to address the devastating impacts of early-life adversity on local population health and inequities, we must focus on the dominant social and behavioral mechanisms affecting Nevadans,” said Stephanie Koning, Ph.D., an assistant professor at the School of Public Health at the University of Nevada, Reno, and study co-author. “Beyond how population needs drive our research, we are partnering with community-based organizations to promote evidence-based interventions across individual, community, and state levels.”
As the study team expands their analysis of the health impacts of early-life adversity, they are exploring how to use the Healthy Nevada Project database to inform community-based interventions. They’ve partnered with community institutional partners — including the Stacie Mathewson Behavioral Health & Addiction Institute and Northern Nevada HOPES — for research and advocacy focused on promoting healthy childhood social environments and well-being throughout an individual’s life.
The full text of the study, Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population, is available from Frontiers in Psychiatry: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583677/.
This project was funded by the Stacie Mathewson Behavioral Health and Addiction Institute, Renown Health, and the Renown Health Foundation. Study authors included Karen Schlauch (DRI), Robert Read (DRI), Stephanie Koning (UNR), Iva Neveux (DRI), and Joseph Grzymski (DRI/Renown Health).
For more information on the Healthy Nevada Project®, please visit: https://healthynv.org/.
The Desert Research Institute (DRI) is a recognized world leader in basic and applied environmental research. Committed to scientific excellence and integrity, DRI faculty, students who work alongside them, and staff have developed scientific knowledge and innovative technologies in research projects around the globe. Since 1959, DRI’s research has advanced scientific knowledge on topics ranging from humans’ impact on the environment to the environment’s impact on humans. DRI’s impactful science and inspiring solutions support Nevada’s diverse economy, provide science-based educational opportunities, and inform policymakers, business leaders, and community members. With campuses in Las Vegas and Reno, DRI serves as the non-profit research arm of the Nevada System of Higher Education. For more information, please visit www.dri.edu.
Renown Health is the region’s largest, locally governed, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. With a diverse workforce of more than 7,000 employees, Renown has fostered a longstanding culture of excellence, determination and innovation. The organization comprises a trauma center, two acute care hospitals, a children’s hospital, a rehabilitation hospital, a medical group and urgent care network, and the region’s largest, locally owned not-for-profit insurance company, Hometown Health. Renown is currently enrolling participants in the world’s largest community-based genetic population health study, the Healthy Nevada Project®. For more information, visit renown.org.
About the University of Nevada, Reno
The University of Nevada, Reno, is a public research university that is committed to the promise of a future powered by knowledge. Nevada’s land-grant university founded in 1874, the University serves 21,000 students. The University is a comprehensive, doctoral university, classified as an R1 institution with very high research activity by the Carnegie Classification of Institutions of Higher Education. Additionally, it has attained the prestigious “Carnegie Engaged” classification, reflecting its student and institutional impact on civic engagement and service, fostered by extensive community and statewide collaborations. More than $800 million in advanced labs, residence halls and facilities has been invested on campus since 2009. It is home to the University of Nevada, Reno School of Medicine and Wolf Pack Athletics, maintains a statewide outreach mission and presence through programs such as the University of Nevada, Reno Extension, Nevada Bureau of Mines and Geology, Small Business Development Center, Nevada Seismological Laboratory, and is part of the Nevada System of Higher Education. Through a commitment to world-improving research, student success and outreach benefiting the communities and businesses of Nevada, the University has impact across the state and around the world. For more information, visit www.unr.edu.