Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis

Deciphering the metagenome-encoded pathway	and	domain	 structure for Palmerolide biosynthesis

Project Objective

Antarctic ascidian, Synoicum adareanum NIH ProjectPageOver 1 billion bacterial cells per gram tissue.
Example gene cluster source: Mizuno et al. 2013 PlosOne8:e76021

To identify the Pal producing gene cluster (an antimelanoma gene product) in the microbial metagenome of the Antarctic ascidian, Synoicum adareanum. This entails assembling, annotating and mining the S. adareanum microbial metagenome. Then, a predictive bioorganic synthesis strategy will be applied to identify potential Palmerolide biosynthetic gene clusters. These predictions will be validated using single cell genome sequencing approach to screen candidate organism(s) gene content. 


Project Team

• Alison Murray, DRI (lead)
• Bill Baker, USF, Co-I
• Patrick Chain, LANL, Co-I
• Armand Dichosa, LANL, Senior Scientist


Contact Information

Dr. Alison Murray | This email address is being protected from spambots. You need JavaScript enabled to view it.
Desert Research Instituite | Earth and Ecosystem Sciences


Funded by

DRI | IPA | NIH NCI Clinical and Translational R21

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